Jeffrey L Noebels Selected Research

Q-Type Calcium Channels (Q-Type Calcium Channel)

1/2020	Adult loss of Cacna1a in mice recapitulates childhood absence epilepsy by distinct thalamic bursting mechanisms.
12/2017	Persistent aberrant cortical phase-amplitude coupling following seizure treatment in absence epilepsy models.
1/2016	Isolated P/Q Calcium Channel Deletion in Layer VI Corticothalamic Neurons Generates Absence Epilepsy.
3/2011	Delayed postnatal loss of P/Q-type calcium channels recapitulates the absence epilepsy, dyskinesia, and ataxia phenotypes of genomic Cacna1a mutations.
2/2009	Genetic enhancement of thalamocortical network activity by elevating alpha 1g-mediated low-voltage-activated calcium current induces pure absence epilepsy.

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Jeffrey L Noebels Research Topics

Disease

24	Seizures (Absence Seizure) 10/2021 - 01/2002
23	Epilepsy (Aura) 10/2021 - 01/2002
10	Absence Epilepsy (Childhood Absence Epilepsy) 01/2020 - 05/2005
5	Sudden Unexpected Death in Epilepsy 01/2021 - 02/2014
5	Nervous System Diseases (Neurological Disorders) 01/2020 - 12/2011
5	Ataxia (Dyssynergia) 01/2020 - 09/2003
5	Cognitive Dysfunction 12/2017 - 07/2009
4	Neurodevelopmental Disorders 01/2017 - 11/2004
3	Epileptic Syndromes 03/2013 - 07/2008
3	Rett Syndrome (Rett's Disorder) 07/2011 - 11/2004
2	Brain Diseases (Brain Disorder) 12/2019 - 11/2010
2	Myoclonic Epilepsies (Myoclonic Encephalopathy) 08/2018 - 02/2014
2	Infantile Epileptic-Dyskinetic Encephalopathy 08/2018 - 01/2014
2	Autistic Disorder (Autism) 01/2018 - 11/2010
2	Bradycardia 04/2015 - 08/2012
2	Sudden Death 09/2014 - 08/2012
2	Spasm (Spasms) 01/2014 - 07/2009
1	Gliosis 01/2020
1	Neoplasms (Cancer) 01/2020
1	Dystonia (Limb Dystonia) 01/2020
1	Inflammation (Inflammations) 01/2020
1	Glioma (Gliomas) 01/2020
1	Megalencephaly 11/2019
1	Autism Spectrum Disorder 11/2019
1	Tuberous Sclerosis (Bourneville's Disease) 11/2019
1	Intellectual Disability (Idiocy) 01/2018
1	Inborn Genetic Diseases (Disease, Hereditary) 12/2017
1	Nervous System Trauma 11/2017
1	Glut1 Deficiency Syndrome 01/2017
1	Polymorphic catecholergic ventricular tachycardia 01/2016
1	Cardiac Sudden Death (Sudden Cardiac Arrest) 01/2016
1	Cardiac Arrhythmias (Arrythmia) 01/2016
1	Fibrosis (Cirrhosis) 09/2015
1	Atrial Fibrillation 09/2015
1	Apnea 04/2015
1	Heart Arrest (Cardiac Arrest) 04/2015
1	Infantile Spasms (West Syndrome) 10/2012
1	Atrioventricular Block 08/2012
1	Virus Diseases (Viral Diseases) 12/2011
1	Dyskinesias (Dyskinesia) 03/2011
1	Alzheimer Disease (Alzheimer's Disease) 01/2011
1	Schizophrenia (Dementia Praecox) 11/2010

Drug/Important Bio-Agent (IBA)

7	Proteins (Proteins, Gene)FDA Link 11/2019 - 06/2004
7	Ion Channels (Ion Channel)IBA 09/2015 - 01/2003
6	Potassium Channels (Potassium Channel)IBA 10/2021 - 07/2008
5	Q-Type Calcium Channels (Q-Type Calcium Channel)IBA 01/2020 - 02/2009
4	CalciumIBA 01/2020 - 06/2004
4	Sodium Channels (Sodium Channel)IBA 12/2019 - 01/2002
3	Glutamic Acid (Glutamate)FDA Link 01/2020 - 01/2008
3	Ethosuximide (Zarontin)FDA LinkGeneric 01/2018 - 01/2016
3	AMPA Receptors (AMPA Receptor)IBA 12/2017 - 10/2010
3	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 12/2017 - 01/2013
3	Glucose (Dextrose)FDA LinkGeneric 01/2017 - 04/2006
3	Biological ProductsIBA 01/2016 - 01/2003
3	Methyl-CpG-Binding Protein 2IBA 07/2011 - 11/2004
2	SpectrinIBA 01/2020 - 11/2017
2	Biomarkers (Surrogate Marker)IBA 12/2017 - 01/2016
2	Calcium Channels (Calcium Channel)IBA 01/2016 - 05/2005
2	Pharmaceutical PreparationsIBA 01/2016 - 03/2012
2	Dizocilpine Maleate (Dizocilpine)IBA 01/2016 - 01/2013
2	Neuropeptide YIBA 07/2009 - 07/2008
1	KCNQ2 Potassium ChannelIBA 10/2021
1	GTP-Binding Proteins (G-Protein)IBA 01/2021
1	SteroidsIBA 01/2021
1	5-HT2C Serotonin ReceptorIBA 01/2021
1	Serotonin (5 Hydroxytryptamine)IBA 01/2021
1	Serotonin ReceptorsIBA 01/2021
1	polyalanineIBA 01/2021
1	Hormones (Hormone)IBA 01/2020
1	AntiportersIBA 01/2020
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 11/2019
1	Mechanistic Target of Rapamycin Complex 2IBA 11/2019
1	Mechanistic Target of Rapamycin Complex 1IBA 11/2019
1	TensinsIBA 11/2019
1	Nonsense Codon (Nonsense Mutation)IBA 01/2018
1	Voltage-Gated Sodium ChannelsIBA 01/2018
1	Glucose Transporter Type 1IBA 01/2017
1	RyanodineIBA 01/2016
1	N-Methylaspartate (NMDA)IBA 01/2016
1	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA 01/2016
1	Potassium Chloride FDA LinkGeneric 04/2015
1	4-Aminopyridine (4 Aminopyridine)FDA Link 04/2015
1	voltage-dependent calcium channel (P-Q type)IBA 04/2015
1	SUMO-1 Protein (SUMO Protein)IBA 09/2014
1	ezogabine (retigabine)IBA 09/2014
1	Peptide Hydrolases (Proteases)FDA Link 09/2014
1	Estradiol (Delestrogen)FDA LinkGeneric 01/2014
1	Transcription Factors (Transcription Factor)IBA 01/2014
1	Chloride Channels (Chloride Channel)IBA 03/2013
1	6-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA 01/2013
1	phosphonic acidIBA 01/2013
1	RNA-Binding Proteins (RNA-Binding Protein)IBA 09/2012
1	Atropine FDA LinkGeneric 08/2012
1	Double-Stranded RNA (RNA, Double Stranded)IBA 12/2011
1	eIF-2 Kinase (eIF 2 Kinase)IBA 12/2011
1	Phosphotransferases (Kinase)IBA 12/2011
1	Amyloid (Amyloid Fibrils)IBA 01/2011
1	Aminobutyrates (Aminobutyric Acid)IBA 11/2010
1	gamma-Aminobutyric Acid (GABA)IBA 11/2010

Therapy/Procedure

7	Therapeutics 01/2020 - 11/2002